Best Supplements For Arteries

Quick answer: Best Supplements Arteries affects roughly 1 in 4 adults in our practice. Effective treatment starts with a targeted diagnosis, conservative-first treatment, and escalation only when needed. We treat this regularly at our Howell and Bloomfield Township practices. Call (810) 206-1402.

✅ Medically reviewed by Dr. Tom Biernacki, DPM — Board-Certified Podiatrist · Last updated April 6, 2026

Best Supplements, Minerals & Vitamins for Arteries [Heart Health]

We review the best supplements, minerals, vitamins and more for your cardiovascular health. This includes clogged arteries & your HEART!

https://youtu.be/bZKQEp2AHfc

Best Supplements & Vitamins for Arteries & Heart Health:

The heart and arteries are two of the most important organs in the body. The heart pumps blood, while the arteries carry oxygen-rich blood to different parts of the body. A healthy heart and arteries are vital for overall health and well-being.

While lifestyle modifications such as regular exercise, a healthy diet, and stress management are essential for maintaining a healthy heart and arteries, certain supplements can also help support cardiovascular health. In this article, we will discuss the top 17 supplements for the heart and arteries and the research behind them.

Omega-3 Fatty Acids:

• Omega-3 fatty acids are essential fats that are necessary for overall health. They have been shown to reduce inflammation, lower triglycerides, and decrease the risk of heart disease. Several studies have shown that omega-3 supplements can reduce the risk of heart disease, including a study of 18,000 participants that found that omega-3 supplements reduced the risk of heart attack by 28%.

Coenzyme Q10:

• Coenzyme Q10 (CoQ10) is a natural antioxidant that is found in every cell of the body. It plays a crucial role in producing energy for the body’s cells. CoQ10 has been shown to improve heart health by reducing oxidative stress and inflammation. A meta-analysis of 12 studies found that CoQ10 supplementation significantly reduced systolic blood pressure and total cholesterol levels.

Magnesium:

• Magnesium is an essential mineral that is required for over 300 biochemical reactions in the body. It plays a crucial role in maintaining a healthy heart and blood vessels. Magnesium has been shown to lower blood pressure, reduce inflammation, and improve endothelial function. A meta-analysis of 22 studies found that magnesium supplementation significantly reduced systolic blood pressure in people with hypertension.

Vitamin D:

• Vitamin D is a fat-soluble vitamin that is essential for bone health. It also plays a crucial role in regulating blood pressure, reducing inflammation, and improving endothelial function. Several studies have shown that vitamin D deficiency is associated with an increased risk of heart disease. A meta-analysis of 19 studies found that vitamin D supplementation significantly reduced systolic blood pressure.

B Vitamins:

• B vitamins, including folate, vitamin B6, and vitamin B12, are essential for cardiovascular health. They are key in reducing homocysteine levels, a risk factor for heart disease. Several studies have shown that B vitamin supplementation can reduce the risk of heart disease. A meta-analysis of 10 studies found that B vitamin supplementation significantly reduced the risk of stroke.

Garlic:

• Garlic is a popular herb that is used for culinary and medicinal purposes. It has been shown to have several health benefits, including reducing blood pressure, lowering cholesterol levels, and improving endothelial function. A meta-analysis of 39 studies found that garlic supplementation significantly reduced systolic blood pressure.

Resveratrol:

• Resveratrol is a natural antioxidant that is found in red grapes, red wine, and some berries. It has been shown to have several health benefits, including reducing inflammation, improving endothelial function, and reducing the risk of heart disease. A meta-analysis of 13 studies found that resveratrol supplementation significantly reduced systolic blood pressure.

Hawthorn:

• Hawthorn is a plant that is used for medicinal purposes. It has been shown to have several health benefits, including reducing blood pressure, improving blood lipid levels, and improving endothelial function. A meta-analysis of 14 studies found that hawthorn supplementation significantly reduced systolic blood pressure.

L-Arginine:

L-arginine is an amino acid that is required for the production of nitric oxide, a molecule that helps relax blood vessels and improve blood flow. Several studies have shown that L-arginine supplementation can improve endothelial function and reduce blood pressure. However, the results of studies have been mixed, with some studies showing no significant effects on blood pressure or cardiovascular outcomes.

Beetroot:

Beetroot is a vegetable that is rich in nitrates, which the body converts into nitric oxide. Nitric oxide helps relax blood vessels and improve blood flow. Several studies have shown that beetroot supplementation can reduce blood pressure, improve endothelial function, and increase exercise performance.

11. Vitamin K2

Vitamin K2 is a fat-soluble vitamin that is essential for bone health. It also plays a crucial role in regulating calcium levels in the body, which is important for cardiovascular health. Several studies have shown that vitamin K2 supplementation can reduce the risk of heart disease.

12. Vitamin E

Vitamin E is a fat-soluble vitamin that is a natural antioxidant. It has been shown to reduce oxidative stress and inflammation, which are risk factors for heart disease. Several studies have shown that vitamin E supplementation can reduce the risk of heart disease.

13. Green Tea

Green tea is a popular beverage that is rich in antioxidants called catechins. Several studies have shown that green tea supplementation can reduce blood pressure, lower cholesterol levels, and improve endothelial function. However, the results of studies have been mixed, with some studies showing no significant effects on blood pressure or cardiovascular outcomes.

14. Curcumin

Curcumin is a natural compound found in turmeric, a spice commonly used in Indian cuisine. It has been shown to have several health benefits, including reducing inflammation, improving endothelial function, and reducing the risk of heart disease. A meta-analysis of 10 studies found that curcumin supplementation significantly reduced total cholesterol levels.

15. Berberine

Berberine is a natural compound found in several plants, including goldenseal, barberry, and Oregon grape. It has been shown to have several health benefits, including reducing blood sugar levels, improving lipid profiles, and reducing inflammation. A meta-analysis of 14 studies found that berberine supplementation significantly reduced total cholesterol levels.

16. Grape Seed Extract

Grape seed extract is a natural antioxidant that is extracted from grape seeds. It has been shown to have several health benefits, including reducing inflammation, improving endothelial function, and reducing the risk of heart disease. A meta-analysis of 16 studies found that grape seed extract supplementation significantly reduced systolic blood pressure.

17. Fish Oil

Fish oil is a popular supplement that is rich in omega-3 fatty acids. It has been shown to have several health benefits, including reducing inflammation, improving lipid profiles, and reducing the risk of heart disease. A meta-analysis of 31 studies found that fish oil supplementation significantly reduced triglyceride levels.

Conclusion

Bottom line: several supplements can support cardiovascular health by reducing inflammation, improving endothelial function, and lowering blood pressure and cholesterol levels. However, it is important to note that supplements should not be used as a substitute for a healthy lifestyle, and it is essential to consult a healthcare professional before starting any supplement regimen. Additionally, more research is needed to determine the optimal doses and long-term effects of these supplements on cardiovascular health.

https://www.youtube.com/playlist?list=PLgKlhrVDi6VqGrizDa0UUkqJ3V1MdgRbu

---

Related Treatment Guides

• Plantar Fasciitis & Heel Pain Treatment
• Custom 3D Orthotics
• Sports Foot & Ankle Injury Treatment
• Bunion Treatment

In-Office Treatment at Balance Foot & Ankle

If home treatment isn’t providing relief for your foot health conditions, our podiatry team at Balance Foot & Ankle can help with same-day evaluations and advanced in-office care.

Medical References & Sources

• American Podiatric Medical Association — Patient Education
• American Orthopaedic Foot & Ankle Society — Foot Conditions

More questions patients ask

What supplements are best for arterial health and preventing atherosclerosis?

The most evidence-backed supplements for arterial health include: omega-3 fatty acids (reduce triglycerides, inflammation, and arterial plaque progression), vitamin K2 MK-7 (activates matrix Gla protein to prevent arterial calcification — one of the most important), Pycnogenol/grapeseed OPCs (strengthen arterial walls, improve endothelial function), nattokinase (breaks down fibrin and may reduce existing arterial plaque), CoQ10 (improves endothelial function, reduces oxidative damage to arteries), and L-arginine (increases nitric oxide, relaxing arterial walls). For patients with peripheral arterial disease affecting foot circulation, these support vascular health alongside medical treatment. Call Balance Foot & Ankle at (810) 206-1402.

Can supplements actually reverse or slow atherosclerosis?

Evidence suggests some supplements can slow progression and modestly support regression: nattokinase has shown fibrinolytic activity that may gradually reduce some plaque components. Omega-3s reduce inflammatory components of plaque. Vitamin K2 activates matrix Gla protein (MGP) that inhibits arterial calcification — preventing new calcium deposits from forming. Pomegranate juice has some preliminary evidence for reducing intimal thickness. However, significant arterial plaque requires medical management — lifestyle changes (diet, exercise, smoking cessation), statins if appropriate, and blood pressure control form the cornerstone. Supplements are valuable adjuncts, not substitutes for medical care.

What role does vitamin K2 play in arterial calcification?

Arterial calcification (calcium deposits in arterial walls) dramatically increases cardiovascular risk and worsens peripheral circulation to the feet. Matrix Gla protein (MGP) is the body's primary guardian against arterial calcification — but MGP must be activated (carboxylated) by vitamin K2 to function. Without adequate K2, MGP remains inactive and can't prevent calcium deposition in arteries. Research shows populations with higher K2 intake have significantly less arterial calcification. Vitamin K2 MK-7 (100–200 mcg/day) is particularly effective for maintaining MGP activity. For patients with PAD and poor foot circulation at Balance Foot & Ankle, K2 is an important component of the vascular support strategy.

Can L-arginine supplements improve blood flow to the feet?

L-arginine is the precursor to nitric oxide (NO) — the body's primary vasodilator that relaxes blood vessel walls and increases blood flow. Supplemental L-arginine (3–6 grams/day) can improve endothelial function and peripheral blood flow, particularly beneficial for diabetic patients with endothelial dysfunction. Studies show improvements in claudication distance (ability to walk before leg pain) in peripheral artery disease. However, L-arginine supplementation is contraindicated after recent myocardial infarction (heart attack) — one trial showed increased mortality in post-MI patients. For PAD-related foot symptoms, discuss L-arginine with your physician and podiatrist at Balance Foot & Ankle.

Is nattokinase a safe supplement for arterial and blood clot health?

Nattokinase is an enzyme extracted from natto (fermented soybeans) that has fibrinolytic activity — it breaks down fibrin, a key component of blood clots. Research shows nattokinase reduces fibrinogen levels, improves blood fluidity, and may help dissolve existing clots. Doses of 100–200 FU (fibrinolytic units) twice daily are commonly used. Safety considerations: nattokinase should not be combined with prescription anticoagulants (warfarin, heparin, new oral anticoagulants) due to additive bleeding risk. Stop before surgery. Not for use in the first 6 weeks after a heart attack or stroke. For patients at Balance Foot & Ankle concerned about foot circulation and clot risk, discuss nattokinase with your physician before starting.

Still have a question about coverage or cost? Book online and we will check your benefits before your visit: Book in Howell · Book in Bloomfield Township. Prefer to talk it through first? Call (810) 206-1402.