Metformin-Induced B12 Deficiency Neuropathy

Peripheral Neuropathy Home Remedies [Leg & Foot Nerve Pain Treatment]

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Metformin & Vitamin B12 Deficiency Neuropathy

Quick Answer: Long-term metformin use depletes vitamin B12, causing peripheral neuropathy in some diabetics. The neuropathy may be mistaken for diabetic neuropathy. Test B12 annually if on metformin.

Solution

B12 supplementation (oral or injection) usually reverses or stabilizes symptoms. Have your B12 tested if you are on metformin and have neuropathy.

FAQ

Should I stop metformin?

Not usually — B12 supplementation typically resolves the issue. Discuss with your endocrinologist.

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Frequently Asked Questions

When should I see a podiatrist?

If symptoms persist past 2 weeks, affect your normal activity, or are accompanied by red-flag symptoms (warmth, redness, swelling, inability to bear weight).

What does treatment cost?

Most diagnostic visits and conservative treatments are covered by Medicare and major insurers. Out-of-pocket costs vary by your specific plan.

How quickly can I get an appointment?

Most non-urgent cases see us within 5 business days. Urgent cases (sudden pain, possible fracture) typically same or next business day.

Balance Foot & Ankle surgeons are affiliated with Trinity Health Michigan, Corewell Health, and Henry Ford Health — three of Michigan’s largest health systems.